Novel nitric oxide producing probiotic wound healing patch: preparation and in vivo analysis in a New Zealand white rabbit model of ischaemic and infected wounds.

Novel nitric oxide producing probiotic wound healing patch: preparation and in vivo analysis in a New Zealand white rabbit model of ischaemic and infected wounds.

Int Wound J. 2012 Jan 6;

Authors: Jones M, Ganopolsky JG, Labb� A, Gilardino M, Wahl C, Martoni C, Prakash S

Abstract
The treatment of chronic wounds poses a significant challenge for clinicians and patients alike. Here we report design and preclinical efficacy of a novel nitric oxide gas (gNO)-producing probiotic patch for wound healing. Specifically, a wound healing patch using lactic acid bacteria in an adhesive gas permeable membrane has been designed and investigated for treating ischaemic and infected full-thickness dermal wounds in a New Zealand white rabbit model for ischaemic wound healing. Kaplan-Meier survival curves showed increased wound closure with gNO-producing patch-treated wounds over 21 days of therapy (log-rank P = 0�0225 and Wilcoxon P = 0�0113). Cox proportional hazard regression showed that gNO-producing patch-treated wounds were 2�52 times more likely to close compared with control patches (hazard P = 0�0375, score P = 0�032 and likelihood ratio P = 0�0355), and histological analysis showed improved wound healing in gNO-producing patch-treated animals. This study may provide an effective, safe and less costly alternative for treating chronic wounds.

PMID: 22221913 [PubMed - as supplied by publisher]

Source: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=22221913&dopt=Abstract

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